A ameaça global da resistência antimicrobiana - A necessidade de instrumentos de vigilância padronizados para definir carga e desenvolver intervenções

Anti-microbial resistance (AMR) is one the biggest issues the medical community is currently facing, as evidenced by the increasing prevalence of pan-resistant strains. In addition to treatment options, AMR also has major financial and economical implications. It has been estimated that up to 50% of antimicrobial use is inappropriate; each year approximately 2 million people in the US are infected with a resistant organism. Up to 23,000 yearly deaths are reportedly caused directly by such infections. The situation is further complicated in low-income countries by lack of effective surveillance systems, laboratory diagnostics, and access to appropriate antimicrobials in the face of financial limitations. The emergence of MDR Gram-negative bacterial (GNB) resistance is particularly of concern, especially in intensive care units (ICUs) and immunocompromised patients,